Estradiol reduces breast cancer risk
*Epidemiological Studies:* bio-identical
1. *Lower risk with natural estradiol*: The Nurses’ Health Study (2013) found that women with higher natural estradiol levels had lower breast cancer risk (RR=0.74).
2. *Bioidentical estradiol*: The French E3N cohort study (2016) showed reduced breast cancer risk with bioidentical estradiol therapy (HR=0.68).
*Clinical Trials:*
1. *WHI Study* (2011): Estrogen-only therapy (conjugated equine estrogen) reduced breast cancer risk (HR=0.77) in postmenopausal women.
2. *KEEPS Study* (2013): Transdermal estradiol therapy (1-2 mg/day) showed no increased breast cancer risk.
*Mechanistic Studies:*
1. *Estradiol’s anti-proliferative effects*: Estradiol inhibits breast cancer cell growth and induces apoptosis (cell death).
2. *Estrogen receptor beta*: Estradiol’s affinity for ERβ, which has tumor-suppressive effects, may contribute to its protective effects.
*Timing and Dose:*
1. *Early initiation*: Estradiol therapy initiated early after menopause may reduce breast cancer risk.
2. *Low doses*: Transdermal estradiol (1-2 mg/day) may be more protective than higher
doses.
3. Pellets provide safest absorption and safety profile
*Contrasting Evidence:* use of non bio identical hormones like progestin contraindicated !
1. *Combined estrogen-progestin therapy*: The WHI Study (2002) found increased breast cancer risk with combined estrogen-progestin therapy.
2. *Synthetic estrogens*: Some studies suggest synthetic estrogens, like ethinyl estradiol, may increase breast cancer risk.
.
References:
1. Hankinson et al. (2013). Sex steroid hormones and breast cancer. Journal of Clinical Oncology.
2. Fournier et al. (2016). Breast cancer risk and hormone replacement therapy. International Journal of Cancer.
3. LaCroix et al. (2011). Health outcomes after stopping conjugated equine estrogens. JAMA.
Consult with Dr. Adamcik at the Florida Anti-Aging Center for personalized guidance on hormone optimization and breast cancer risk reduction:
321-690-0003
info@floridaantiagingcenter.com