Estradiol in women
Women, I have bad news. You have been lied ! You and been told that estrogen increases risk for breast cancer. This is completely untrue. There is no evidence to support this! You are much less likely to get breast cancer if you have estrogen. And if you get breast cancer, you are much more likely to survive if you have estrogen.
The controversy is 20 years old now! In 1997, The women’s health initiative was started. This enrolled woman aged 65 or older (way past menopause the optimal start time) to 3 groups. Some too Premarin only (an oral horse estrogen) some took a combination of Premarin with Provera ( a chemically altered progesterone ) and there was a control population
In 2002 the study was stopped due to higher incidence of cardiovascular disease and breast cancer. The official statistics were still pending and at this time , the public paired taking Premarin as cancer causative.
It took 2 years to fully analyze the data. In 2004, the final report was different than the initial warning. The Premarin only arm was NOT FOUND TO INCREASE BREAST CANCER! It was only on the Premarin plus Provera that the cancers where increased
Unfortunately giving horse estrogen by mouth was not entirely safe either. Oral administration of estrogen goes through liver metabolism. This increase inflammation , sugar intolerance, weight gain, and higher cardiovascular risk These ill effects can be voided by administering the estrogen in I a cream or pellet form
It is the artificial hormone progestin that has been implicated in breast cancer and other cancers but never estrogen Numerous studies show as much as a 37 % reduction in breast cancer with HRT that includes estrogen.
So, the bad news is that many women have avoided hormone therapy because of fear of breast cancer. But the end result of this is that they will be much more susceptible to dementia.
Women that get a hormone replacement therapy are 58% less likely to get dementia than those that do not get HRT. The reason is that the woman’s brain is critically dependent upon estrogen. estrogen improves brain function. In its absence, the brain’s starts to decline rapidly.
That is bad for most women, but there are some women that it is Bad. There are heredity receptor types (called ERS 1) that can have catastrophic results! in these women (if the receptor is not stimulated with estrogen, the cell sends out inflammatory destructive signals! It is essentially a self-destruct mechanism ! You can decline much more rapidly! The women likely to have this receptor may suffer with migraine headaches or endometriosis.
Estrogen has been shown to decrease overall mortality by about 28%. It decreases cardiovascular disease if it is not taken by mouth.
Estrogen reduces neuro inflammation and therefore it decreases neurodegenerative diseases. It regulates other nerves and controls a number of serotonin receptors, the happy neurotransmitter. For women that have problems with stress and nonfunctioning of hormones. The supplements quercetin and dim are useful.