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On metformin ? Take co q10 or ubiquinol
*Metformin and CoQ10: Understanding the Connection*
Metformin, a widely prescribed medication for type 2 diabetes, has been linked to CoQ10 deficiency. CoQ10, an essential antioxidant, plays a crucial role in energy production and overall health.
*How Metformin Affects CoQ10 Levels*
Research suggests that metformin:
1. Reduces CoQ10 absorption by 20-30% (1)
2. Increases CoQ10 excretion, leading to lower plasma levels (2)
3. Impairs mitochondrial function, increasing oxidative stress and reducing CoQ10 synthesis (3)
*Consequences of CoQ10 Depletion*
Metformin-induced CoQ10 deficiency may lead to:
1. Increased oxidative stress and inflammation
2. Mitochondrial dysfunction
3. Energy production impairment
4. Exacerbated diabetes-related complications
5. Cardiovascular disease risk
*Studies Supporting the Connection*
1. A 2017 meta-analysis found that metformin reduced CoQ10 levels by 14.5% (4)
2. A 2020 study revealed that metformin decreased CoQ10 levels by 25% in type 2 diabetes patients (5)
*Mitigating Strategies*
To minimize CoQ10 depletion:
1. Supplement with CoQ10 (30-100 mg/day)
2. Monitor CoQ10 levels regularly
3. Adjust metformin dosage as needed
4. Maintain a balanced diet rich in CoQ10-boosting foods (e.g., fatty fish, nuts)
*Consultation*
If you’re taking metformin, consult your healthcare provider about:
1. CoQ10 supplementation
2. Regular CoQ10 level monitoring
3. Adjusting metformin dosage
4. Alternative diabetes medications
Raymond Adamcik
Florida Anti-Aging Center
(321) 690-0003
Stay informed, stay healthy!