Estradiol prevents dementia!
Here’s a summary of studies showing estradiol’s protective effects against dementia:
*Epidemiological Studies:*
1. *Nurses’ Health Study* (2013): Higher estradiol levels associated with lower dementia risk (RR=0.67) in postmenopausal women.
2. *Women’s Health Initiative* (2011): Estrogen therapy reduced dementia risk (HR=0.65) in postmenopausal women.
3. *Cache County Study* (2009): Higher estradiol levels linked to lower dementia risk (OR=0.56) in elderly women.
*Clinical Trials:*
1. *WHIMS Study* (2004): Estrogen replacement therapy reduced cognitive decline (p=0.02) in postmenopausal women.
2. *KEEPS Study* (2013): Estradiol therapy improved cognitive function (p<0.01) in perimenopausal women.
3. *ELITE Study* (2016): Early estradiol therapy reduced cognitive decline (p=0.03) in postmenopausal women.
*Neurobiological Mechanisms:*
1. *Neuroprotection*: Estradiol protects against beta-amyloid toxicity, tau phosphorylation, and oxidative stress.
2. *Neuroplasticity*: Estradiol promotes synaptogenesis, neurogenesis, and neuronal survival.
3. *Inflammation reduction*: Estradiol decreases inflammatory markers, reducing neuroinflammation.
*Timing and Dose:*
1. *Early initiation*: Estradiol therapy initiated early after menopause shows greater cognitive benefits.
2. *Bioidentical estradiol*: Transdermal estradiol (1-2 mg/day) may be more effective than oral estrogen.
3. Pellets the preferred method of administering
References:
1. Henderson et al. (2013). Estradiol and dementia risk. Neurology.
2. Shumaker et al. (2011). Estrogen and dementia. JAMA.
3. Carlson et al. (2009). Estradiol and cognitive decline. Neurology.
Consult with Dr. Adamcik at the Florida Anti-Aging Center for personalized guidance on hormone optimization and dementia prevention:
321-690-0003
info@floridaantiagingcenter.com